Table 2.

Cosinor analysis parameters of core clock and chondrogenic marker gene expression in chondrogenic cultures following mechanical load (A) and in nonstimulated control cultures (B)

A. Mechanical load
		Mesor
	p	Intercept	Slope	Amplitude	Acrophase	Period	R 2
BMAL1	<.001	1.500	−0.016	−0.121	22.461	21.918	.951
REV‐ERB	<.05	1.330	0.006	−0.600	20.456	20.000	.461
PER2	<.001	1.360	−0.013	−0.178	20.114	22.046	.897
PER3	<.01	1.145	−0.007	0.240	28.000	25.007	.731
CRY1	<.05	1.402	−0.012	−0.152	25.743	20.000	.809
CRY2	.32	1.278	−0.010	0.086	16.331	20.000	.610
SOX6	<.01	2.757	−0.037	0.556	12.211	20.000	.792
SOX9	<.01	3.306	−0.038	1.096	10.163	22.238	.670
ACAN	<.01	2.030	−0.017	0.380	11.668	21.596	.758
COL2A1	.09	1.165	−0.003	−0.313	18.668	20.000	.373
RUNX2	.15	2.093	−0.023	0.243	10.450	28.000	.664

B. Nonstimulated (control)
		Mesor
	p	Intercept	Slope	Amplitude	Acrophase	Period	R 2
BMAL1	.89	1.069	0.000	0.053	8.595	28.000	.065
REV‐ERB	.61	0.980	0.001	−0.038	9.172	28.000	.189
PER2	.91	0.944	0.001	0.026	20.138	20.000	.065
PER3	.98	1.040	0.000	0.019	16.282	21.919	.020
CRY1	.55	1.012	0.001	0.064	15.970	21.246	.250
CRY2	.92	1.006	−0.001	−0.029	17.095	20.997	.074
SOX6	.89	1.536	0.023	0.402	11.812	28.000	.574
SOX9	.72	0.930	0.000	−0.039	10.010	28.000	.141
ACAN	.79	0.911	0.002	0.034	22.502	20.000	.201
COL2A1	.92	1.005	0.001	0.043	17.526	21.491	.053
RUNX2	.77	0.862	0.003	−0.033	11.199	23.373	.360

Note: p, probability value; R ², coefficient of determination.