TABLE 4.

Associations between sleep apnea during REM‐sleep (REM‐OSA) and intima thickness in men and women

REM‐OSA and intima thickness in men and women
	N	Median (IQR)	Age‐adjusted			Adjusted Model 1			Adjusted Model 2
			β‐coef.	(95% CI)	p	β‐coef.	(95% CI)	p	β‐coef.	(95% CI)	p
Men REM‐AHI, events/h
0–4.9	151	0.08 (0.07–0.09)	Ref			Ref			Ref
5–14.9	73	0.08 (0.08–0.09)	0.026	−0.016 to 0.068	0.217	0.023	−0.021 to 0.066	0.299	0.031	−0.014 to 0.076	0.179
15–29.9	53	0.08 (0.08–0.09)	0.007	−0.041 to 0.055	0.774	0.007	−0.043 to 0.057	0.783	0.024	−0.031 to 0.079	0.387
≥30	61	0.08 (0.08–0.09)	0.027	−0.018 to 0.073	0.241	0.022	−0.027 to 0.071	0.371	0.036	−0.015 to 0.087	0.168
Women REM‐AHI, events/h
0–4.9	71	0.08 (0.07–0.09)	Ref			Ref			Ref
5–14.9	40	0.09 (0.08–0.09)	0.042	−0.023 to 0.107	0.207	0.044	−0.022 to 0.110	0.187	0.058	−0.009 to 0.125	0.088
15–29.9	46	0.08 (0.08–0.10)	0.032	−0.033 to 0.096	0.331	0.038	−0.028 to 0.103	0.263	0.049	−0.018 to 0.116	0.153
≥30	96	0.09 (0.08–0.10)	0.075	0.018 to 0.133	0.010	0.074	0.014 to 0.133	0.015	0.079	0.019 to 0.139	0.010

AHI, apnea‐hypopnea index; CI, confidence interval; coef., coefficient; IQR, interquartile range; OSA, obstructive sleep apnea; REM, rapid eye movement.

Results from linear regression analysis with log‐transformed intima thickness as dependent variable. Model 1 adjusted for age, body mass index, alcohol, and smoking. Model 2 adjusted for age, body mass index, alcohol, smoking, systolic blood pressure, low‐density lipoprotein, C‐reactive protein, and diabetes.