Figure 5.

Glucose tolerance in response to ricin injection. The mice were injected ip with 30 µg/kg of ricin. A glucose tolerance test was administered at 4, 16 and 24 h post ricin administration. The mice were fasted for 6 h prior to administration of 2 mg glucose/g body weight administered ip. Blood was sampled at 0, 15, 30, 60, and 120 m post glucose injection. (A) Change in blood glucose from a normalized baseline blood glucose level. The mean blood glucose levels prior to glucose injection were 103.0 mg/dL, 95.3 mg/dL, 70.3 mg/dL, and 45.3 mg/dL, respectively, for the groups of mice that received no ricin or were injected 4, 16 and 24 h post ricin administration. Each experimental group contained 4–5 mice, and the data represent the mean and SEM for each group. (B) Area under the curve calculated from data in panel A. Mean and SEM are shown. One-way ANOVA was performed. The Kruskal–Wallis test with Dunn’s correction for multiple comparison vs. the control group was performed and no statistical significance was observed.