Figure 1.

Mimetic tissue model preparation. (A) Homogenate preparation: punching of 8 mm biopsies (1), cutting in smaller pieces for a homogenization tube with water and 2 steel homogenization beads (2), homogenization (3), deposition of homogenate into a dosing pipette (4), centrifugation (5) and the frozen dosing pipette with homogenate (6). (B) Embedding and cryo-sectioning of the homogenate: embedding of the homogenates in a 5% CMC gel (1), cryo-sectioning of mimetic tissue model (2) and final section of the mimetic tissue model (3).