Fig. 2.

Assembly of tetraspanin‐enriched macrodomains drives migrasome formation. (A) Tetraspanin‐enriched microdomains (dark red ovals, right panels) are evenly distributed along the retraction fiber prior to migrasome biogenesis. (B) When migrasome biogenesis starts, tetraspanin‐enriched microdomains start to assemble on the migrasome formation site. Such assembly leads to formation of a bulge on the retraction fiber. (C) Eventually, the bulge becomes a spherical vesicle when enough tetraspanin‐enriched microdomains are assembled.