Table 3.
Annualized atrophy rates (percent change in volume per year) of thalamic and extra-thalamic structures with 95% confidence bounds and p-values adjusted for multiple comparisons. Bold numbers indicate change that is significantly different from zero.
| Hemisphere | Structure | Mean Volumetric Change Per Year | 95% Confidence Bound-Lower Limit | 95% Confidence Bound-Upper Limit | Adjusted P-Value |
|---|---|---|---|---|---|
|
| |||||
| Left | Cerebral Cortex | −0.15% | −0.23% | −0.08% | <0.001 |
| Left | Cerebral White Matter | −0.10% | −0.19% | 0.00% | 0.052 |
| Left | Cerebellar Cortex | −0.24% | −0.35% | −0.14% | <0.001 |
| Left | Cerebellar White Matter | −0.06% | −0.25% | 0.14% | 1 |
| Left | Amygdala | −0.03% | −0.14% | 0.09% | 1 |
| Left | Hippocampus | 0.00% | −0.10% | 0.10% | 1 |
| Left | Caudate | −0.11% | −0.24% | 0.03% | 0.31 |
| Left | Putamen | −0.19% | −0.29% | −0.09% | <0.001 |
| Left | Nucleus Accumbens | −0.44% | −0.58% | −0.30% | <0.001 |
| Left | Pallidum | 0.01% | −0.12% | 0.14% | 1 |
| Left | Lateral Ventricle | 1.74% | 1.10% | 2.42% | <0.001 |
| Left | Thalamus | −0.45% | −0.55% | −0.35% | <0.001 |
| Left | AV | −1.18% | −1.43% | −0.93% | <0.001 |
| Left | MD | −0.43% | −0.55% | −0.30% | <0.001 |
| Left | Pulvinar | −0.65% | −0.79% | −0.50% | <0.001 |
| Left | LGN | −0.72% | −1.05% | −0.38% | <0.001 |
| Left | MGN | −0.67% | −0.83% | −0.50% | <0.001 |
| Left | VA | −0.51% | −0.71% | −0.30% | <0.001 |
| Left | VLA | −0.18% | −0.67% | 0.34% | 0.999 |
| Left | VLP | −0.30% | −0.45% | −0.14% | <0.001 |
| Left | CM | −0.62% | −0.84% | −0.39% | <0.001 |
| Left | VPL | −0.36% | −0.57% | −0.15% | <0.001 |
| Left | Habenula | −0.15% | −0.38% | 0.10% | 0.704 |
| Right | Cerebral Cortex | −0.15% | −0.23% | −0.07% | <0.001 |
| Right | Cerebral White Matter | −0.09% | −0.19% | 0.00% | 0.075 |
| Right | Cerebellar Cortex | −0.25% | −0.36% | −0.14% | <0.001 |
| Right | Cerebellar White Matter | 0.00% | −0.20% | 0.20% | 1 |
| Right | Amygdala | −0.03% | −0.15% | 0.09% | 1 |
| Right | Hippocampus | −0.01% | −0.12% | 0.09% | 1 |
| Right | Caudate | −0.21% | −0.32% | −0.10% | <0.001 |
| Right | Putamen | −0.29% | −0.38% | −0.19% | <0.001 |
| Right | Nucleus Accumbens | −0.54% | −0.68% | −0.39% | <0.001 |
| Right | Pallidum | 0.03% | −0.07% | 0.14% | 1 |
| Right | Lateral Ventricle | 1.61% | 1.03% | 2.22% | <0.001 |
| Right | Thalamus | −0.45% | −0.54% | −0.36% | <0.001 |
| Right | AV | −1.08% | −1.31% | −0.84% | <0.001 |
| Right | MD | −0.40% | −0.52% | −0.27% | <0.001 |
| Right | Pulvinar | −0.58% | −0.71% | −0.43% | <0.001 |
| Right | LGN | −0.77% | −1.03% | −0.49% | <0.001 |
| Right | MGN | −0.61% | −0.75% | −0.46% | <0.001 |
| Right | VA | −0.50% | −0.69% | −0.31% | <0.001 |
| Right | VLA | 0.13% | −0.29% | 0.56% | 0.999 |
| Right | VLP | −0.34% | −0.50% | −0.18% | <0.001 |
| Right | CM | −0.62% | −0.83% | −0.41% | <0.001 |
| Right | VPL | −0.28% | −0.47% | −0.09% | <0.001 |
| Right | Habenula | −0.06% | −0.32% | 0.20% | 1 |