FIGURE 5.

Lipid species profiles significantly associated with apolipoprotein E (APOE) gene and prevalent Alzheimer's disease (AD). Meta‐analysis of the Australian Imaging, Biomarkers and Lifestyle (AIBL) and Alzheimer's disease Neuroimaging Initiative (ADNI) cohorts was performed to identify lipid species associated with prevalent AD (linear regression of AD against lipid species, adjusted for APOE ε2, APOE ε4, age, sex, BMI, total cholesterol, HDL‐C, and triglycerides). Linear regression of APOE ε4 (A) or APOE ε2 (B) against lipid species, adjusted for age, sex, BMI, total cholesterol, HDL‐C, and triglycerides was performed in the in Busselton Health Study (BHS) cohort. The beta‐coefficients for lipid species significant in both analyses were plotted against each other. Dark closed circles highlight species that are in a concordant direction with ε4 risk increase (A) or ε2 risk reduction (B)