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Propionate and butyrate inhibited HDAC1 expression and increased Ac‐H3K9 levels in microglia in GF rats. Germ‐free rats were orally administered PBS (GF), sodium propionate (300 mg kg−1, GF‐Pro) or sodium butyrate (300 mg kg−1, GF‐But) for 7 days. A) The expression of HDAC1 in microglia (n = 6). Microglia, green; HDAC1, red; nuclei, blue. B) The level of Ac‐H3K9 in microglia (n = 6). Microglia, green; Ac‐H3K9, red; nuclei, blue. *, p < 0.05; **, p < 0.01.
