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Interaction sites relevant for MCL1 function. (A) Conserved positions of BH3 domains (h1–h4) required to establish interactions with the binding groove. (B) Crystal structure of MCL1 with the P1–P4 pockets of the binding groove highlighted. (C) Crystal structure of MCL1 with the loop relevant for senescence regulation highlighted in red. The figure was generated using PDB code 6YBJ.
