Table 2.

Main identified animal models and their application in the study of MCL1.

Model type		Application		Reference
Knockout MCL1	Absolute KO−/−	Development/Hematopoiesis	Survival of stem cells	[78]
	Conditional KO−/− tissue‐specific	Hematopoiesis	Maintenance of lymphocytes	[85]
			Survival of hematopoietic lineages	[82, 196]
			Megakaryocytic lineage	[83]
		Development	Neurogenesis	[79]
		Pathology	Chronic liver disease and liver tumorigenesis	[121, 122, 123, 197, 198, 199, 200]
			Breast cancer	[201]
			Pancreatic β‐cell survival	[120]
			Neutrophil regulator in cerebral stroke	[118]
	Conditional KO−/− tissue‐specific inducible	Hematopoiesis	Survival of stem cells	[84]
			Survival plasma cells	[202]
		Pathology	Acute myeloid leukemia	[203]
			Liver disease	[204]
			Mitochondrial homeostasis and heart disease	[95, 205]
	Conditional KO+/− tissue‐specific inducible	Hematopoiesis	Activated B‐cell survival and B‐cell memory	[206, 207]
		Pathology	Lymphomas	[208]
			Neurodegeneration	[209]
			Neutrophil regulator in cerebral stroke	[118]
Knockin MCL1	KI human MCL1	Comparative biology	Orthologous proteins	[210, 211]
	KI humanized MCL1 mice	Pharmacological role	Drug efficacy	[158]
			Breast cancer	[159]
		Pathology	Allergy and inflammation	[119]
	KI degradation resistant	Pharmacological role	Colon cancer	[212]