TABLE 2.

Summary of consensus comments for interpretation of biochemical profiles of AD biomarkers in CSF

amyloid	t‐tau	p‐tau(181)	Consensus comments
N	N	N	Biochemical profile not consistent with Alzheimer's disease.
P	P	P	Biochemical profile consistent with Alzheimer's disease.
P	N	N	Biochemical profile consistent with an amyloidopathy.
N	P	N	Biochemical profile not consistent with Alzheimer's disease; may be consistent with other neurodegenerative disease and/or neuronal damage. (If t‐tau is close to/above upper limit of detection with a high t‐tau/p‐tau[181] ratio, the profile may indicate Creutzfeldt‐Jakob disease)
P	P	N	Atypical biochemical profile; may be consistent with Alzheimer's disease.
P	N	P	Atypical biochemical profile; consistent with Alzheimer's disease.
N	P	P	Atypical biochemical profile; not consistent with Alzheimer's disease.
N	N	P	Atypical biochemical profile; not consistent with Alzheimer's disease.

Note to be added to all comments: This biochemical profile must be interpreted in its clinical context and in conjunction with a physician.

Abbreviations: N, normal; P, pathological; p‐tau(181), tau phosphorylated at threonine 181.; t‐tau, total tau.