Table 2.

Characteristics and general biomedical applications of different types of nanogels in chemotherapy.

Nanogel	Description	Drug Delivered	Application	Pre-Clinical/Clinical Study	Ref
DMMA-modified nanogel	Acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and Dox delivery	Dox	Chemotherapy	In vitro cell viability of MDA-MB-435s cells	[75]
polysaccharide-based nanogel	Hyaluronic-Acid-Based pH-Sensitive Nanogels	Dox	Chemotherapy	In vitro cell viability and In vivo mice model tumor volume evaluation	[146]
PEGylated PMAA-based nanogel	Glutathione-sensitive nanogel	Dox	Chemotherapy	In vitro cell viability of HepG2 cells	[147]
HA-based nanogel	Self-targeting hyaluronate (HA) nanogels (CDDPHANG/Dox)	Dox and Cisplatin	Chemotherapy	In vitro cell viability of MCF-7/ADR breast cancer cells	[113,148]
pNIPAAm nanogels	Photothermo-Responsive Nanogel	5-fluorouracil	Chemo-photothermal synergistic therapy	In vitro L929 cell mortality
GO-hybridized pNIPAM nanogels	Photothermally Enhanced Chemotherapy Delivered by Graphene Oxide-based Multi-responsive Nanogels	Dox	Chemo-photothermal synergistic therapy	In vitro cell viability of HeLa cells	[149,150]
Folated PVA-based nanogels	Folated pH degradable PVA nanogels	Docetaxel	Chemo-immunotherapy	In vitro cell viability of 4T1 breast cancer cells	[151]