Figure 1.

Representation of enniatin B1 (ENN B1), T-2 toxin (T-2), zearalenone (ZEN), aflatoxin B1 (AFB1) and drugs as CYP450 substrates and potential CYP450 perpetrators, following the gastrointestinal tract to the liver where metabolism occurs. A schematic drawing is given on the possible pathways that might take place in the human liver. In the bottom-right corner, a legend is displayed. At the bottom-center an explanation is given for ENN B1, T-2, ZEN and AFB1, as CYP3A4 substrates and as pregnane X receptor inducer in case of ZEN, on the possible impact on metabolism.