Table 3.
Summary of the impact of mycotoxins on CYP450 enzymes and receptors. The summary comprises data of in vitro and in vivo animal experiments, across species.
| Mycotoxin | Induction | Inhibition | In Vitro/In Vivo | References |
|---|---|---|---|---|
| aflatoxin B1 | CYP1A2 CYP2B6 CYP2C9 CYP3A4 CYP3A5 |
CYP1A1 (rabbits) CYP3A6 (rabbits) |
In vitro | [76,78] |
| deoxynivalenol | CYP2B | / | In vitro (mice) | [76,79] |
| T-2 toxin | / | CYP1A1 CYP1A2 CYP2A1 CYP2B4 CYP1A4 CYP1A5 CYP3A37 |
In vivo (rabbits) In vivo (chicken) |
[80] [81] |
| zearalenone | PXR-receptor | / | In vitro | [77] |
| fumonisin B1 | CYP1A4 (chicken) CYP2E1 (rats) |
CYP1A2 (rats) CYP2C11 (rats) |
In vivo | [76,82,83] |
| enniatin B1 | / | CYP2C19 | In vitro | [84] |