Table 3.

Effects of Resveratrol against Cervical Cancer: in vivo animal studies.

Cell	Resveratrol Concentration/Duration	Effect	Reference
Female BALB/C nude mice subcutaneously injected 2 × 106 HeLa cells/mL (100 µL/mouse)	10 mg/kg RSV orally, daily for 28 days	↓Tumor weight ↑PLSCR1	[52]
C57BL/6 female mice injected with TC-1 (HPV oncogene E6, E7 positive) cells subcutaneously	Injection of RSV intralesionally administrated for 5 days	↓Tumor size ↑cell cycle arrest ↓Tumor E6 levels ↓Tumor VEGF levels ↓Tumor PCNA levels	[67]
Athymic BALB/C nude mice subcutaneously injected 5 × 106 HeLa cells/mouse	30 mg/kg RSV intragastrically, 3 times/week for 2 weeks (pre-treatment)	↓Tumor volume ↓Tumor weight ↓STAT3 protein levels ↓MMP-3/13 protein levels ↑E-cadherin ↓N-cadherin protein levels ↓Vimentin protein levels	[56]
Female BALB/C nude mice subcutaneously injected 2 × 106 HeLa cells/mouse	30 mg/kg RSV orally, 3 times/week for 3 weeks	↓Tumor volume ↓Tumor weight ↓E6/7 mRNA levels ↓E6/7 protein levels ↑p53 expression ↑Rb1 expression	[69]
Female BALB/C nude mice subcutaneously injected 2 × 106 HeLa cells/mL (100 µL/mouse)	15 mg/kg RSV intragastrically, 3 times/week for 5 weeks	↓Tumor volume ↓Tumor weight ↓E6/7 mRNA levels ↓E6/7 protein levels ↓p-pRb1 ↑p53 expression	[59]