Table 2.
Univariate and multivariate analyses of OS in GBM cohorts.
| Characteristics | Total (N) | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | p Value | Hazard Ratio (95% CI) | p Value | ||
| Sex | 208 | ||||
| male | 124 | Reference | |||
| female | 84 | 1.032 (0.761–1.400) | 0.839 | ||
| Age | 208 | 1.025 (1.011–1.040) | <0.001 | 1.025 (1.010–1.039) | <0.001 |
| Location | 208 | 1.110 (1.004–1.228) | 0.042 | 1.047 (0.944–1.162) | 0.385 |
| KPS | 208 | ||||
| ≤50 | 23 | Reference | |||
| >50 | 185 | 0.150 (0.095–0.237) | <0.001 | 0.253 (0.148–0.431) | <0.001 |
| Chemoradiotherapy | 208 | ||||
| no | 63 | Reference | |||
| yes | 145 | 0.066 (0.043–0.103) | <0.001 | 0.136 (0.075–0.245) | <0.001 |
| Resection | 208 | ||||
| STR | 83 | Reference | |||
| GTR | 125 | 0.199 (0.145–0.275) | <0.001 | 0.433 (0.276–0.680) | <0.001 |
| MGMT | 208 | ||||
| no | 121 | Reference | |||
| yes | 87 | 0.419 (0.306–0.573) | <0.001 | 0.654 (0.452–0.945) | 0.024 |
| WBC | 208 | ||||
| ≤6.7 | 127 | Reference | |||
| >6.7 | 81 | 1.622 (1.198–2.197) | 0.002 | 0.979 (0.597–1.606) | 0.934 |
| Neu | 208 | ||||
| ≤4.9 | 134 | Reference | |||
| >4.9 | 74 | 2.540 (1.863–3.461) | <0.001 | 1.040 (0.588–1.839) | 0.892 |
| Lym | 208 | ||||
| ≤1.9 | 151 | Reference | |||
| >1.9 | 57 | 0.546 (0.382–0.782) | <0.001 | 0.830 (0.550–1.251) | 0.373 |
| PLT | 208 | ||||
| ≤255 | 168 | Reference | |||
| >255 | 40 | 1.546 (1.070–2.234) | 0.020 | 0.710 (0.461–1.096) | 0.122 |
| Monocyte | 208 | ||||
| ≤0.4 | 77 | Reference | |||
| >0.4 | 131 | 1.358 (0.990–1.862) | 0.058 | 1.390 (0.945–2.047) | 0.095 |
| NLR | 208 | ||||
| ≤2.1 | 69 | Reference | |||
| >2.1 | 139 | 2.820 (1.992–3.993) | <0.001 | 1.769 (1.106–2.829) | 0.017 |
| PLR | 208 | ||||
| ≤249.3 | 187 | Reference | |||
| >249.3 | 21 | 2.478 (1.547–3.969) | <0.001 | 2.598 (1.473–4.581) | <0.001 |
| LMR | 208 | ||||
| ≤2.3 | 52 | Reference | |||
| >2.3 | 156 | 0.461 (0.328–0.646) | <0.001 | 0.899 (0.590–1.371) | 0.621 |
| SII | 208 | ||||
| ≤510.8 | 100 | Reference | |||
| >510.8 | 108 | 2.226 (1.638–3.025) | <0.001 | 1.782 (1.168–2.719) | 0.007 |
Abbreviations: KPS, Karnofsky performance status; GTR, gross total resection; STR, subtotal resection; IDH, isocitrate dehydrogenase; MGMT, O6-methylguanine-DNA methyltransferase; WBC, white blood cell; Neu, neutrophil; Lym, lymphocyte; PLT, platelet; SII, systemic immune-inflammation index; HR, hazard ratio; CI, confidence interval.