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Strategies for mRNA loading into EVs. Strategies are classified into pre-loading methods and post-loading methods. The former can be further divided into passive and active methods. ARRDC1, arrestin domain containing protein 1; Tat, transactivator of transcription protein; TAR, trans-activating response element; MS2P, MS2 bacteriophage coat protein; HUR, human antigen R; MVs, microvesicles; ARE, AU-rich elements; ZF, zinc finger motif.
