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Genome organization and structure of human adenovirus type 5. (A) Schematic representation of the adenoviral genome, transcription units, and major proteins. (B) Structural representation of adenovirus and its components. E, early region (shown as red arrows); L, late region (shown as black arrows); L’-ITR, left inverted terminal repeat; R’-ITR, right inverted terminal repeat; Ψ, packaging signal; AdPol, adenovirus DNA polymerase; TP, terminal protein; DBP, DNA-binding protein.
