Table 4.
Epidemiological, clinical and pathological patterns of patients diagnosed with vaginal and vulvar cancer (n = 21).
| Pre-Pandemic (2019) | Pandemic with High Restrictions (2020) | Pandemic Recovery (2021) | p | |
|---|---|---|---|---|
| Number of patients, n | 8 | 8 | 5 | |
| Age at diagnosis, median (IQR; Min-Max), years | 71.0 (21; 54–86) | 80.0 (17; 72–96) | 68.0 (42; 32–89) | 0.095 |
| Postmenopausal status, n (%) | 8 (100.0) | 8 (100.0) | 3 (60.0) | 0.029 * |
|
Histological type, n (%) Squamous cell carcinoma Melanoma Paget´s disease of the vulva Basal cell carcinoma |
4 (50.0) 1 (12.5) 1 (12.5) 2 (25.0) |
7 (87.5) 0 (0.0) 0 (0.0) 1 (12.5) |
5 (100.0) 0 (0.0) 0 (0.0) 0 (0.0) |
0.440 |
|
Tumor staging1, n (%) Initial stage (IA, IB) Advanced stage (II-IV) Unknown |
5 (62.5) 0 (0.0) 3 (37.5) |
5 (62.5) 3 (37.5) 0 (0.0) |
2 (40.0) 3 (60.0) 0 (0.0) |
0.051 |
| Time between first MDTM and treatment initiation, median (IQR; Min-Max), days | 27.0 (-; 27–74) | 27.0 (23; 13–43) | 49.0 (73; 21–131) | 0.354 |
|
Therapeutic management, n (%) Chemoradiotherapy Surgery 2 Palliative No treatment 3 |
0 (0.0) 3 (37.5) 0 (0.0) 5 (62.5) |
0 (0.0) 5 (62.5) 1 (12.5) 2 (25.0) |
2 (40.0) 3 (60.0) 0 (0.0) 0 (0.0) |
0.053 |
| Hospitalization days, median (Min-Max) | 21.0 (-; 3–44) | 30.0 (37; 3–45) | 9.0 (-; 3–12) | 0.448 |
| Intra- and post-operative complications 4, n (%) | 1 (33.3) | 4 (80.0) | 1 (33.3) | 0.302 |
| Time between surgery and histological assessment, median (Min-Max), days | 50.0 (-; 16–90) | 30.0 (26; 12–42) | 31.0 (-; 25–35) | 0.517 |
Legend: IQR—interquartile range; MDTM—multidisciplinary team meeting. 1 Tumor staging was assessed using the revised International Federation of Gynecology and Obstetrics (FIGO) Classification 2009 [19] and TNM Classification of Malignant Tumors (TNM) 2017 [22]. 2 In two cases, patients were submitted to neoadjuvant chemoradiotherapy. 3 Patients under surveillance, lost to follow-up or death. 4 Pre-pandemic (2019): infection and dehiscence of the surgical wound (n = 1); pandemic with high restrictions (2020): vulvar hemorrhage (n = 1), infection and dehiscence of the surgical wound (n = 3); pandemic recovery (2021): infection and dehiscence of the surgical wound (n = 1). * Statistically significant differences for a significance level of 0.05.