TABLE 2.

Predetermined data items extracted from individual studies

Patient information and historyGender Age Primary Diagnosis and comorbid conditions Medications and allergies Type of bisphosphonate used and dosage Duration of bisphosphonate therapy History of current adverse event Major symptoms described from the patient Onset, location, duration of the symptoms Previous history of mucosal adverse events (before treatment with bisphosphonate) Clinical findings Health screening assessment (blood pressure, body temperature) Extraoral examination Intraoral examination Inspection and documentation of the mucosal adverse event (location, distribution and definition, size, shape, colour, consistency, texture) Nikolsky's sign examination Adjunctive visual tools (such as toluidine blue, fluorescence visualisation) Coexistence on other mucosae Differential Diagnosis Diagnostic tests Haematological and serological assays Saliva analysis Histopathological examination Suggested management Medical intervention/Drug holiday/Alteration of the medication Time until resolution of symptoms/Healing period