Table 4.

Characteristics of the current laboratory methods for LNP preparation.

Name	Cost	Scalability	Encapsulation Efficiency	Reproducibility	Polydispersity Index
Ethanol dilution method	Low	Moderate	Moderate	Moderate	High
Manual mixing method	Low	Low	Low	Low	High
T-mix method	Low	High	High	High	Moderate
Microfluidics	High	High	High	High	Low