Salivary (A) and vaginal (B) IgA Ab responses to SBR after i.n. immunization of mice with SBR alone, SBR-CTA2/B, or SBR-LT-IIaA2/B. Results are the arithmetic means + standard deviations (error bars) of eight mice per group. In panel A, ∗ and ∗∗ indicate statistically significant differences at P < 0.05 and P < 0.01, respectively, compared to SBR–LT-IIaA2/B.