FIG. 5.

Dose-response effect of SBR-CTA2/B and SBR–LT-IIaA2/B on B7-1 and B7-2 expression by NALT (A) or splenic (B) or CLN (C) B220⁺ B cells. B220⁺ B cells were incubated for 20 h with various concentrations of chimeric protein and then costained with anti-B7-1 and anti-B7-2. Results shown are expressed as the arithmetic means ± standard deviations (error bars) of three experiments. ∗ and ∗∗, statistically significant differences at P < 0.05 and P < 0.01, respectively, compared to SBR-LT-IIaA2/B.