Table 1.
Putative OSC markers and phenotypes.
| Marker | Cell Origin | Phenotype |
|---|---|---|
| CD133 | Saos-2, MG-63, U2-OS, MNNG/HOS, 143B, HOS, Human primary cells | High stem cells gene expression, sphere formation, side population, increased cell proliferation [26,27,28,29,30]. |
| CD117/Stro-1 | K7M2, KHOS/NP, MNNG/HOS, 318–1, P932, BCOS | High stem cells gene expression, sphere formation, drug resistance, in vivo tumorigenicity and metastatic potential [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. |
| CD271 | Human primary (FFPE), MNNG/HOS, U2-OS, Saos-2 | High stem cells gene expression, sphere formation, drug resistance, in vivo tumorigenicity [32]. |
| Aldehyde dehydrogenase | MG-63, OS99–1 Hu09, Saos-2 | High stem cells gene expression, sphere formation, drug resistance, increased cell proliferation [33,34]. |
| Stem cells antigen-1 | 4 Murine osteosarcoma cell lines | Sphere formation, in vivo tumorigenicity [35,36] |
| Fas apoptotic inhibitory molecule 2 | MNNG/HOS, U2-OS | Sphere formation, drug resistance, in vivo tumorigenicity [37]. |
| Side population | OS2000, KIKU, NY, Huo9, HOS, U2OS, Saos-2, human primary |
High stem cells gene expression, Sphere formation, in vivo tumorigenicity, self-renewal, apoptosis resistant [38,39,40]. |
| Sphere formation | MG-63, MNNG/HOS, human primary | High stem cells gene expression, drug resistance, in vivo tumorigenicity [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,41,42]. |