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RANK/RANKL/OPG pathway where osteoblastic cell populations regulate the osteoclasts (C) cell populations. Pre-osteoblasts (P), osteoblasts (B), and osteocytes(S) secrete RANKL causing an increase in osteoclasts. Osteoblasts and osteocytes also inhibit osteoclastogenesis by secreting OPG, a competitive inhibitor of RANKL.
