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(A) Structure of human DPP-4 depicted in surface representation. The β-propeller domain is colored green and the α/β hydrolase domain is colored blue. The S1 and S2 pockets are also marked. The catalytic triad (Ser630, Asp708 and His 740) is shown in ball and stick representation. (B) The boxed region in (A) is enlarged to show the active site and the catalytic triad.
