Table 1.
Amino acid sites under diversifying or purifying selection for each protein-encoded region of the Omicron BA.1 and BA.2 sub-lineages.
| BA.1 | BA.2 | |||||
|---|---|---|---|---|---|---|
| ORFs | dN/dS | Diversifying Selection | Purifying Selection | dN/dS | Diversifying Selection | Purifying Selection |
| ORF1ab | 0.580 | nsp3 (2710); nsp4 (3255); nsp5 (3395); nsp6 (3646, 3758); nsp12 (5063); nsp14 (5967) | nsp2 (341, 735); nsp3 (1120, 1707, 1750, 1903, 2676); nsp4 (2907); nsp5 (3290, 3458); nsp6 (3689); nsp10 (4310); nsp12 (4992); nsp13 (5444, 5541) | 0.525 | - | nsp2 (440); nsp3 (924, 1707, 2470, 2551); nsp4 (3100, 3245); nsp5 (3271, 3311); nsp13 (5616, 5746); nsp15 (6566); nsp16 (6819) |
| S | 0.981 | RBD (339, 346, 371, 375, 440, 446, 452, 484, 493, 505); SD1/SD2 (554); S2 (796, 1260) | SP (11); SD1/SD2 (543); S2 (1146) | 0.653 | - | NTD (296); RBD (336, 410) |
| ORF3a | 2.040 | - | - | 1.266 | - | - |
| E | 0.401 | - | - | 0.341 | - | 67, 68 |
| M | 0.201 | - | 135 | 0.477 | 3 | - |
| ORF6 | 0.259 | - | - | 0.597 | - | - |
| ORF7a | 1.52 | - | - | 1.91 | - | - |
| ORF7b | 1.67 | - | - | 1.37 | - | - |
| ORF8 | 0.563 | - | - | 0.986 | - | - |
| N | 0.812 | 215 | 73, 324 | 0.880 | - | 329 |
| ORF10 | 0.319 | - | - | 0.970 | - | - |