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. 2022 Dec 6;14(12):2726. doi: 10.3390/pharmaceutics14122726

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Histological images of dorsal wounds in adults male Wistar rats (Rattus norvegicus) obtained 2, 7, or 12 days after injury and daily local application of treatments based in the plant marcela (Achyrocline satureioides) extracts and controls. ST: without treatment; Hg: hydrogel treatment; HNE: treatment with blank nanoemulsion; and HNE_AS: treatment with hydrogel incorporating A. satureioides extract. (A) inflammatory process; (B) hemorrhage; (C) edema; (D) neoangiogenesis; (E) collagen; and (F) re-epithelialization. Mallory’s trichrome staining. Magnification: 200×, scale 100 µm.