Table 2.
Permeation/retention of flavonoids from HNEAS in the different skin layers of porcine ear skin using Franz-type diffusion cells.
| Tape Stripping | Without Epidermis | |||||
|---|---|---|---|---|---|---|
| QCT | LUT | 3MQ | QCT | LUT | 3MQ | |
| Epidermis (µg/cm2) |
0.62 ± 4.10 | 0.42 ± 5.70 | 1.60 ± 3.9 | - | - | - |
| Dermis (µg/cm2) |
0.12 ± 9.30 | 0.09 ± 12.0 | 0.19 ± 6.70 | 0.8 ± 8.3 a | 0.5 ± 11.0 a | 1.9 ± 9.7 a |
| Fluid (µg/mL) | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ |
Where: QCT: Quercetin; LUT: Luteolin; and 3MQ: 3-O-methylquercetin; LOQ: Limit of quantification; Deviations are expressed as relative standard deviation (%). Analysis of variance followed by the Tukey test, a statistical difference in Dermis between Without Epidermis and Tape Stripping (p < 0.05), n = 5.