Figure 1.

Regulatory behavior of livers from patients with AH. (A) Patient disease states for which RNA-seq was performed. (B) Clinical parameters from serum samples for each patient. (C) Hierarchical clustering of RNA-seq data reveals two clusters: AH Down-reg with 789 genes and AH Up-reg with 2769 genes. (D) Most interconnected PPI interaction network, as calculated by MCODE Cytoscape application, for AH Down-reg gene cluster. (E) Most interconnected PPI interaction network for AH Up-reg gene cluster. In Figure 1 (D,E), nodes (proteins) are colored by their function in a specific metabolic pathway while edge thickness is determined by the confidence score, which is computed by the STRING database.