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Glutathione (GSH) metabolism and transport activity is sequentially dysregulated with increasing AH severity. As AH severity increases, the earlier the steps in the GSH metabolism pathway are affected. While the early ASH disease state affects the last step in the pathway when GSH is exported, the explant AH state affects the first step in the pathway when methionine is imported to produce cysteine. Created with BioRender.com (accessed on 19 November 2022).
