Table 2. Associations between changes in proteins at 3 or 6 months after anthracyclines and change in GLS at 3 months in the breast cancer discovery cohort.
FAP, fibroblast activation protein; BDNF/INT-3, brain-derived neurotrophic factor/neurotrophin-3; EGF, epidermal growth factor.
| Protein | Pearson’s R
3 months (n = 30) |
Nominal P value | Pearson’s R
6 months (n = 12) |
Nominal P value | Data supporting aptamer specificity |
|---|---|---|---|---|---|
| Hemopexin | −0.59 | 5.0 × 10−4 | −0.52 | 8.6 × 10−2 | † |
| E-selectin | 0.53 | 2.5 × 10−3 | −0.18 | 0.6 | *, †, ║ |
| Interleukin-17D | 0.52 | 3.1 × 10−3 | 0.00 | 1.0 | * |
| Contactin-1 | 0.50 | 5.1 × 10−3 | 0.27 | 0.4 | *, †, ║ |
| Interleukin-17 receptor A | −0.49 | 6.4 × 10−3 | −0.24 | 0.5 | *, †, ‡, §, ║ |
| Serum amyloid P-component | −0.47 | 9.3 × 10−3 | 0.34 | 0.3 | *, †, ‡, § |
| Creatine kinase B-type | 0.47 | 9.4 × 10−3 | 0.40 | 0.2 | *, † |
| CD209 antigen | 0.46 | 1.0 × 10−2 | 0.13 | 0.7 | *, †, ‡, § |
| Ribonuclease H1 | 0.45 | 1.3 × 10−2 | 0.13 | 0.7 | * |
| Neurogenic locus notch homolog protein 3 | 0.45 | 1.3 × 10−2 | 0.02 | 1.0 | *, †, ║ |
| Netrin-4 | 0.44 | 1.4 × 10−2 | −0.01 | 1.0 | *, †, § |
| Galactoside 3(4)-l-fucosyltransferase | −0.44 | 1.4 × 10−2 | 0.15 | 0.6 | *, †, ‡, § |
| Neuregulin-1 | 0.44 | 1.4 × 10−2 | −0.24 | 0.5 | * |
| Plexin-C1 | 0.44 | 1.6 × 10−2 | 0.24 | 0.5 | *, †, ‡, § |
| Casein kinase II 2-α:2-β heterotetramer | −0.44 | 1.6 × 10−2 | 0.15 | 0.6 | * |
| Leptin | 0.43 | 1.7 × 10−2 | 0.23 | 0.5 | †, ║ |
| Prolyl endopeptidase FAP | 0.43 | 1.8 × 10−2 | −0.05 | 0.9 | * |
| Dynein light chain roadblock-type 1 | −0.43 | 1.8 × 10−2 | 0.24 | 0.5 | † |
| Glutathione S-transferase P1 | −0.42 | 1.9 × 10−2 | −0.11 | 0.7 | *, †, § |
| Leukocyte immunoglobulin-like receptor subfamily B member 1 | 0.42 | 2.2 × 10−2 | −0.20 | 0.5 | *, †, ‡, § |
| Mannose-binding protein C | −0.41 | 2.4 × 10−2 | −0.54 | 7.1 × 10−2 | *, †, ‡, §, ║ |
| C-type lectin domain family 4 member K | −0.40 | 2.7 × 10−2 | −0.16 | 0.6 | *, †, § |
| Platelet glycoprotein Ib α chain | −0.40 | 2.8 × 10−2 | −0.19 | 0.5 | *, †, § |
| BDNF/NT-3 growth factors receptor | 0.40 | 2.9 × 10−2 | 0.13 | 0.7 | * |
| Contactin-2 | 0.40 | 2.9 × 10−2 | 0.13 | 0.7 | *, †, ‡, § |
| Prolactin | 0.40 | 3.0 × 10−2 | −0.51 | 9.0 × 10−2 | * |
| C-C motif chemokine 16 | −0.40 | 3.1 × 10−2 | −0.01 | 1.0 | *, †, ‡, §, ║ |
| Junctional adhesion molecule-like | 0.40 | 3.1 × 10−2 | −0.13 | 0.7 | †, § |
| C-C motif chemokine 27 | −0.39 | 3.5 × 10−2 | −0.26 | 0.4 | *, † |
| Somatotropin | 0.38 | 3.7 × 10−2 | 0.09 | 0.8 | *, † |
| Follistatin-related protein 1 | 0.37 | 4.3 × 10−2 | −0.25 | 0.4 | *, †, § |
| Teratocarcinoma-derived growth factor 1 | 0.37 | 4.4 × 10−2 | −0.21 | 0.5 | *, †, ‡, § |
| l-Selectin | 0.37 | 4.5 × 10−2 | −0.31 | 0.3 | *, †, ‡, §, ║ |
| Interleukin-6 receptor subunit α | 0.37 | 4.7 × 10−2 | −0.36 | 0.3 | *, †, ‡, §, ║ |
| EGF-containing fibulin-like extracellular matrix protein 1 | 0.36 | 4.8 × 10−2 | −0.12 | 0.7 | *, †, § |
| Interleukin-1 receptor antagonist protein | −0.03 | 0.9 | −0.72 | 8.6 × 10−3 | *, †, §, ║ |
| Tumor necrosis factor receptor superfamily member 10A |
0.01 | 1.0 | 0.67 | 1.8 × 10−2 | * |
| Angiogenin | −0.32 | 8.2 × 10−2 | −0.63 | 3.0 × 10−2 | *, †, ‡, ║ |
| Apolipoprotein B | −0.32 | 8.6 × 10−2 | −0.59 | 4.2 × 10−2 | *, †, ‡ |