Figure 3.

IL-33 deficiency diminishes pulmonary inflammatory responses in mice with ARDS. (a) Total cell counts and neutrophil counts in BALF. (b) The expression of inflammatory mediators, including TNF-α, IL-1β, and IL-6, in BALF was detected by ELISA. (c) Pulmonary permeability was assessed by BALF protein analysis. (d) Lung tissue edema was measured by the lung W/D ratio. The data are expressed as the means ± SDs. Significant differences are shown by ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001 by one-way ANOVA followed by Bonferroni's post hoc test comparing the WT control, LPS, LPS+rmIL-33, and LPS+IL-33^−/− groups. N = 3‐5 for each group, and three independent repeated experiments were carried out.