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Generalized additive model with Cox proportional hazard ratios of PFS benefit in veliparib-throughout arm 3 versus placebo arm 1 according to KELIM in (A) patients with BRCA mutation, (B) BRCA wild-type HRD cancer, and (C) HRP cancer. The cutoff at 0.024 was the KELIM median value. HRD, homologous recombination deficiency; HRP, homologous recombination proficiency; KELIM, elimination rate constant K; PFS, progression-free survival.
