Table 2.
| |||||
---|---|---|---|---|---|
Entry |
Solvent |
Base/additive |
3 a [%][b] |
4 a [%][b] |
Selectivity 3 a/4 a |
1 |
DMAc |
K3PO4 |
27 |
31 |
0.87 |
2 |
DMAc |
K3PO4/TBACl |
9 |
46 |
0.19 |
3 |
DMAc |
K3PO4/TBAF⋅H2O |
– |
42 |
– |
4 |
DMAc |
K3PO4/TBABr |
12 |
45 |
0.27 |
5 |
DMAc |
K3PO4/TBAI |
4 |
13 |
0.31 |
6 |
DMAc |
K3PO4/TBA[HSO4] |
3 |
38 |
0.08 |
7 |
DMAc[c] |
NaOMe |
73 |
27 |
2.70 |
8 |
DMAc[c] |
NaOMe/TBACl |
7 |
93 |
0.08 |
9 |
DMAc[c] |
NaOMe/NaCl[d] |
28 |
13 |
2.15 |
10 |
DMAc[c] |
NaOMe/KCl[d] |
38 |
12 |
2.92 |
11 |
DMAc[c] |
NaOMe/NH4Cl |
30 |
34 |
0.88 |
[a] 1 equiv.=0.5 mmol, Atmospheric conditions unless otherwise noted. [b] Isolated yield. [c] Argon atmosphere. [d] 0.125 m solution in DMAc.