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. 2022 Dec 24;8:102. doi: 10.1038/s41522-022-00366-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Overview of sampling regions showing the 8 towns selected in Jiaoling (world’s longevity township), the Guangdong province of southern China. 16S rRNA gene and metagenomics sequence analysis and in in vitro and in vivo verification experiment process. b The phylogenetic relationship of top 100 species and age-related strains at the genus level. Statistical analysis between groups was expressed as mean ± SD, error bars were standard deviation.