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. 2022 Dec 24;8:102. doi: 10.1038/s41522-022-00366-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Relative abundances of age-related gut microbiota Lactobacillus, Akkermansia, Methanobrevibacter, Alistipes, Parabacteroides, Uncl Erysipelotrichaceae, Butyrivibrio, Butyricimonas, Barnesiella, Phascolarctobacterium, Roseburia, Uncl Clostridiales, and Uncl Ruminococcaceae between younger (Y20, Y40, Y60) and older (Y80, Y100, Y120) groups by Wilcoxon rank-sum test, * indicates p < 0.05; ** indicates p < 0.01; *** indicates p < 0.001. b Co-occurrence network analysis of gut microbiota at the genus level. Different nodes represent different genera, the size of the node represents the average relative abundance of the genus, the nodes of the same phylum have the same color, and the thickness of the line between nodes is positively correlated with the absolute value of the correlation coefficient of species interaction. The positive and negative correspondence between the color of the connection and the correlation (red positive correlation, blue negative correlation).