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. 2022 Dec 24;8:102. doi: 10.1038/s41522-022-00366-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Correlations between the relative abundance of selected bacterial family and clinical parameters. Correlations with p < 0.05 are shown. Spearman’s rho statistic adjusted using the Benjamini and Hochberg method. Age years old, Hei height, Wei weight, BMI body mass index, NCE neck circumference, ACE abdominal circumference, WSBP systolic blood pressure, WDP diastolic blood pressure, CHO cholinesterase, ALB albumin, GLO globulin, γ-GPE γ-glutamyl transpeptidase, ALK alkaline phosphatase, AST aspartate aminotransferase, TBN total bilirubin, ALT alanine aminotransferase, Ca calcium, BUN urea nitrogen, UA uric acid, Cr creatinine, CHOL total cholesterol, TG triglycerides, HDL.c high-density lipoprotein, LDL.c low-density lipoprotein. HBA1c glycated hemoglobin, PLC platelet count, WBCC white blood cell count, LAV absolute lymphocyte value, NAV absolute value of neutrophils, Hb hemoglobin concentration. b Clinical parameters of all the groups. Changes in clinical indicators of different age groups. * indicates p < 0.05; ** indicates p < 0.01; *** indicates p < 0.001; ns not significant, one-way ANOVA analysis of variance and expressed as mean ± SD, error bars were standard deviation.