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. 2022 Dec 24;8:102. doi: 10.1038/s41522-022-00366-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a, b Features identified by ultra-high-resolution mass spectrometry of different metabolites significantly up-regulated and down-regulated in the LP group compared to the model group. The volcano chart can visually display the overall distribution of different metabolites. The significantly up-regulated metabolites are represented by red dots, the significantly down-regulated metabolites are represented by green dots, and the size of the dot represents the VIP value. c KEGG pathway enrichment bubble chart. The larger the value of abscissa, the higher the enrichment of differential metabolites in the pathway. The color of the dot represents the p-value of the hypergeometric test. The smaller the value, the greater the reliability of the test and the more statistically significant. The size of the dot represents the number of different metabolites in the corresponding pathway. The larger the dot, the more differential metabolites in the pathway. d Correlation diagram of different metabolites (the pos is the positive ion mode, the neg is the negative ion mode). Positive correlation is red, and negative correlation is blue. The part without color indicates p-value > 0.05, The figure shows the correlation of the top20 differential metabolites sorted by p-value from small to large. e Diagram of related pathways of L-ascorbate.