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. 2022 Dec 23;12:22273. doi: 10.1038/s41598-022-26915-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The bile acid TUDCA reduces age-related hyperinsulinemia and improves cognition in aged mice. TUDCA treatment for 20 days attenuated hyperinsulinemia and improved glucose homeostasis in 18-month-old mice, by enhancing liver IDE expression and insulin clearance. Furthermore, the improvement in glucose-insulin homeostasis in these mice was accompanied by a reduction in body weight, adiposity, and adipocyte hypertrophy, associated with reduced TG and CHOL levels in the liver. TUDCA-treated aged mice also displayed increased energy expenditure and ameliorated cognitive ability. In summary, these findings highlight TUDCA as an interesting target for the attenuation of age-related hyperinsulinemia and its deleterious effects on metabolism.