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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Trends Biochem Sci. 2022 Jul 7:S0968-0004(22)00146-3. doi: 10.1016/j.tibs.2022.06.005

Figure 1. Structure of human AGO2 bound to a small RNA.

Figure 1.

(A) Domain organization of human AGO2. (B) The 5′ and 3′ termini of the small RNA (in black) are buried in the AGO MID and PAZ domains (PDB ID: 4W5N) [10]. Protein structures were rendered by UCSF ChimeraX [109].