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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Trends Biochem Sci. 2022 Jul 7:S0968-0004(22)00146-3. doi: 10.1016/j.tibs.2022.06.005

Figure 2. Mechanisms of global miRNA turnover.

Figure 2.

(A) During T-cell activation, AGO proteins are ubiquitylated by an unknown ubiquitin ligase and undergo proteasome-mediated degradation, resulting in global miRNA decay [24]. (B) Poxvirus Vp55 adenylates human miRNAs, leading to their degradation by an unknown nuclease(s) [25]. (C) Wispy adenylates miRNAs during the maternal-to-zygotic transition in Drosophila embryos, leading to global clearance of maternal miRNAs [26]. Figure created with Biorender.com.