TABLE 3.

Specificity and sensitivity of PancRISK and plasma CA19‐9, alone and in combination—(A) Sensitivity (SN) at fixed specificity (SP) for PancRISK (i), CA19‐9 (ii) and combined PancRISK and CA19‐9; (B) SP at fixed SN for PancRISK (i), CA19‐9 (ii) and combined PancRISK and CA19‐9

(A) Sensitivity (95% CI) at fixed specificity
Specificity	0‐1 year	0‐2 years	0‐3 years	0‐4 years	0‐5 years
(i) PancRISK: Sensitivity (95% CI) at fixed specificity
0.75	0.667	0.421	0.339	0.342	0.364
0.8	0.5	0.368	0.254	0.256	0.242
0.85	0.444	0.29	0.22	0.171	0.162
0.9	0.389	0.237	0.17	0.073	0.111
0.95	0.167	0.184	0.102	0.012	0.02
(ii) CA19‐9: Sensitivity (95% CI) at fixed specificity
0.75	0.722	0.553	0.475	0.439	0.448
0.8	0.589	0.459	0.373	0.343	0.333
0.85	0.5	0.368	0.322	0.268	0.263
0.9	0.472	0.342	0.271	0.22	0.195
0.95	0.389	0.29	0.22	0.171	0.141
(iii) PancRISK + CA19‐9: Sensitivity (95% CI) at fixed specificity
0.75	0.833	0.658	0.542	0.476	0.475
0.8	0.778	0.605	0.458	0.402	0.384
0.85	0.778	0.54	0.373	0.305	0.283
0.9	0.722	0.447	0.305	0.244	0.202
0.95	0.5	0.29	0.237	0.171	0.141

(B) Specificity (95% CI) at fixed sensitivity
Sensitivity	0‐1 year	0‐2 years	0‐3 years	0‐4 years	0‐5 years
(i) PancRISK: Specificity (95% CI) at fixed sensitivity
0.75	0.687	0.49	0.394	0.303	0.349
0.8	0.586	0.399	0.328	0.263	0.268
0.85	0.546	0.303	0.197	0.207	0.217
0.9	0.52	0.212	0.141	0.167	0.141
0.95	0.5	0.177	0.111	0.126	0.086
(ii) CA19‐9: Specificity (95% CI) at fixed sensitivity
0.75	0.742	0.515	0.52	0.51	0.489
0.8	0.576	0.475	0.479	0.461	0.421
0.85	0.515	0.373	0.373	0.401	0.333
0.9	0.358	0.302	0.273	0.315	0.258
0.95	0.263	0.253	0.194	0.227	0.151
(iii) PancRISK + CA19‐9: Specificity (95% CI) at fixed sensitivity
0.75	0.854	0.576	0.47	0.475	0.53
0.8	0.773	0.535	0.444	0.45	0.399
0.85	0.712	0.48	0.381	0.384	0.338
0.9	0.596	0.424	0.318	0.333	0.278
0.95	0.561	0.359	0.242	0.268	0.202