Table 3.
Independent Associations of hsTnI with CVD events (n = 2896).
| hsTnI (ng/L) | Coronary Heart Disease (n = 51) | Ischemic Stroke (n = 30) | Heart Failure (n = 46) | All (n = 116) |
|---|---|---|---|---|
| Hazard Ratios (95% CI); p-value | ||||
| <4 (n = 1715; 59.2%) | ||||
| Model 1 | 1.00 | 1.00 | 1.00 | 1.00 |
| Model 2 | 1.00 | 1.00 | 1.00 | 1.00 |
| 4–10 (n = 1039; 35.8%) | ||||
| Model 1 | 3.21 (1.72–5.98); 0.0003 | 1.66 (0.77–3.61); 0.20 | 1.98 (1.03–3.80); 0.04 | 2.35 (1.57–3.51); <.0001 |
| Model 2 | 2.78 (1.48–5.22); 0.002 | 1.55 (0.71–3.42); 0.27 | 1.39 (0.70–2.73); 0.35 | 2.06 (1.37–3.09); 0.0005 |
| >10 (n = 142; 4.9%) | ||||
| Model 1 | 4.87 (1.88–12.57); 0.001 | 3.82 (1.24–11.75); 0.02 | 6.54 (2.88–14.84); <.0001 | 4.95 (2.77–8.83); <.0001 |
| Model 2 | 4.75 (1.83–12.32); 0.001 | 3.81 (1.22–11.86); 0.02 | 3.29 (1.33–8.13); 0.01 | 4.78 (2.66–8.59); <.0001 |
| 1 SD increment in log (hsTnI) | ||||
| Model 1 | 1.32 (1.16–1.49); <.0001 | 1.30 (1.07–1.58); 0.01 | 1.36 (1.20–1.53); <.0001 | 1.32 (1.21–1.44); <.0001 |
| Model 2 | 1.31 (1.15–1.50); <.0001 | 1.29 (1.05–1.58); 0.02 | 1.28 (1.09–1.52); 0.003 | 1.30 (1.19–1.43); <.0001 |
Model 1: age- and race/ethnicity-adjusted.
Model 2: adjusted for age, race/ethnicity, smoking, BMI, hypertension, glycemic status, total cholesterol/HDL ratio, cholesterol lowering drugs, hs-CRP.
Model 2 for heart failure adjusts also for BNP.