Fig. 3.

Reduction of NOC1, NOC2 and NOC3 during development affects the number and size of the ommatidia by inducing apoptosis but does not affect the differentiated ommatidia. Photographs of Drosophila compound eyes (lateral view) expressing the indicated transgenes using the GMR-Gal4 promoter (A–E) or the tubulin-GAl4 promoter in combination with eyeless-flippase to constrain Gal4 expression to the proliferative cells of the eye and antenna (F–J) (Bellosta et al., 2005). (K–M) Photographs of compound eyes expressing the caspase inhibitor P35 alone (K) or together with NOC1-RNAi (M) that rescues the eye defect showed in L. Photographs were acquired from male's eyes and similar data were obtained using females (not shown). (N,O) Quantification of eye size from F–J (N) and from K–M (O); values are expressed as the mean±s.d. percentage of control, set at 100% (n=10). ***P<0.001; ****P<0.0001; n.s., not significant (unpaired two-tailed Student's t-test). Scale bars: 250 µm.