Table 1.

Description of baseline measures in patients who developed MSA-P

Variable	Case 1	Case 2	Case 3	Case 4
Sex	M	F	M	F
Duration of RBD symptoms	4	2	6	6
Prodromal Interval Baseline to MSA (y)	2.5	1.3	2.8	2.6
Family History
Parkinsonism	No	No	No	No
Dementia	No	Yes	No	Yes
RBD Symptoms	No	No	No	No
Sleep Variables
Tonic REM %	43	45	25	52
Phasic REM %	34	39	14	32
Apnea-Hypopnea Index	0.9	12.9	N/A	0.8
Other Sleep Symptoms (self-report)	Insomnia	Insomnia	Insomnia	Mild Somnolence
Insomnia Severity Index	15	23	18	9
Epworth Sleepiness Scale	3	7	7	9
Pittsburgh Sleep Quality Index	10	13	10	6
Motor Variables
UPDRS Part III	1	9	0	0
UPDRS Part II	2	3	0	0
Alternate Tap Test (normal ∼> 175)	239	197	194	162
Purdue PegBoard (normal ∼> 10)	12	13	13	11.5
Timed Up and Go (s)	5	7	5.5	8.5
Cognition
MoCA / 30	27	27	27	27
MCI – neuropsychologic exam	Normal	Normal	Normal	MCI multiple domain
Autonomic function
Orthostatic Symptom Score	1	0	0	0
Systolic Blood Pressure drop (mmHg)	2	–2	0	–4
Urinary Dysfunction Score	0	2	2	1
Erectile Dysfunction Score	0	N/A	1	N/A
Constipation Score	0	0	0	0
Bowel movement Frequency / week	7	7	7	10
Beck Depression Inventory	N/A	9	10	11
Beck Anxiety Inventory	9	2	1	N/A
UPSIT result	11 (Normal)	12 (Normal)	9 (Normal)	10 (Normal)
Color Vision (FM-100 score)	Normal (8)	Abnormal (164)	Abnormal (168)	Normal (128)

MoCA, Montreal Cognitive Assessment; MCI, mild cognitive impairment; UPSIT, University of Pennsylvania Smell Identification Test (12-item cross-cultural version); FM-100, Farnsworth-Munsell 100 Hue test; UPDRS, Unified Parkinson Disease Rating Scale; RBD, REM sleep behavior disorder; MSA, multiple system atrophy.