Table 2.
Baseline variables in MSA versus Lewy body disease
| Variable | MSA | Lewy body | p |
| (n = 4) | disease | (uncorrected) | |
| (N = 63) | |||
| Age | 54.3±7.8 | 69.5±7.9 | < 0.001 |
| Sex (% female) | 50 | 30.5 | 0.58 |
| Duration of RBD symptoms | 4.5±1.9 | 7.4±8.3 | 0.49 |
| Age of RBD onset | 49.8±7.6 | 61.1±10.0 | 0.03 |
| Follow-up Interval baseline to disease (y) | 2.3±0.7 | 3.3±2.7 | 0.46 |
| Total interval symptoms to disease | 6.8±2.6 | 10.7±8.5 | 0.37 |
| Family History (first degree relative) | |||
| Parkinsonism (%) | 0 | 7.9 | 1.0 |
| Dementia (%) | 50 | 14.3 | 0.12 |
| RBD Symptoms (%) | 0 | 7.9 | 1.0 |
| Sleep Variables | |||
| Tonic REM % | 42±12 | 62±26 | 0.13 |
| Phasic REM % | 30±11 | 38±18 | 0.32 |
| Apnea-Hypopnea Index | 4.7±6.7 | 11.5±16.1 | 0.47 |
| Insomnia Severity Index | 16.3±5.9 | 9.7±5.2 | 0.024 |
| Epworth Sleepiness Scale | 6.5±2.5 | 6.6±4.6 | 0.96 |
| Pittsburgh Sleep Quality Index | 9.8±3.1 | 7.3±3.9 | 0.93 |
| Motor Variables | |||
| UPDRS Part III | 2.5±4.4 | 6.7±5.2 | 0.12 |
| UPDRS Part II | 1.3±1.5 | 2.2±2.2 | 0.52 |
| Alternate Tap Test (normal ∼> 175) | 196±32 | 164±32 | 0.053 |
| Purdue PegBoard (normal ∼> 10) | 12.4±0.75 | 10.5±2.1 | 0.066 |
| Timed Up and Go (s) | 6.5±1.6 | 7.2±1.6 | 0.41 |
| Cognition | |||
| MoCA | 27.0±0 | 24.7±3.3 | 0.16 |
| MCI – neuropsychologic exam (%) | 25 | 47 | 0.61 |
| Autonomic function | |||
| Orthostatic Symptom Score | 0.25±0.5 | 0.35±0.6 | 0.73 |
| Systolic Blood Pressure drop (mmHg) | –1.0±2.6 | 17.0±16 | 0.024 |
| Urinary Dysfunction Score | 1.25±0.96 | 0.40±0.58 | < 0.01 |
| Erectile Dysfunction Score | 2±0.75 | 1.6±1.35 | 0.36 |
| (n = 2) | (n = 45) | ||
| Constipation Score | 0±0 | 0.92±0.90 | 0.046 |
| Bowel movement Frequency (per week) | 7.8±1.5 | 6.3±2.8 | 0.32 |
| Bowel movement Frequency < 7 (%) | 0 | 51 | 0.12 |
| Beck Depression Inventory | 10±1.0 | 9.2±6.5 | 0.83 |
| Beck Anxiety Inventory | 4±4.4 | 8.3±8.2 | 0.38 |
| Olfaction – UPSIT result | 10.5±1.3 | 6.1±2.4 | < 0.01 |
| UPSIT % expected for age/sex | 100±13 | 64±25 | < 0.01 |
| Color Vision (FM-100 score) | 125±59.5 | 194±99.4 | 0.17 |
| FM-100 % expected for age | 131±72 | 138±61 | 0.84 |
p values are calculated using t-test and Fisher exact test. They are presented unadjusted for multiple comparisons; given this, and given the low sample size, they are included for information only, and should be considered exploratory in nature. MoCA, Montreal Cognitive Assessment; MCI, mild cognitive impairment; UPSIT, University of Pennsylvania Smell Identification Test (12-item cross-cultural version); FM-100, Farnsworth-Munsell 100 Hue test; UPDRS, Unified Parkinson Disease Rating Scale; RBD, REM sleep behavior disorder; MSA, multiple system atrophy.