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. 2022 Dec 6;90(4):1501–1521. doi: 10.3233/JAD-220824

Fig. 2.

Fig. 2

Age-dependence of intracellular CA1 6E10 and mOC78 immunoreactivity with a large increase at 9 months. A) Low 6E10 immunoreactivity in a 6-month-old female nTg brain. B) Only faint stain in a 6-month-old female 3xTg-AD mouse brain. C) Much stronger stain intensity in the CA1 pyramidal layer of a 9-month-old 3xTg-AD brain. D) Genotype comparison across the age-span shows large increase in 6E10 intensity from 6 to 9 months in 3xTg-AD brains (n = 12 brains/point). E) Largest effect of 9 months rise in 6E10 in female AM mice (n = 3 brains/point). F) Age-effect without a difference between 6E10 3xTg-AD brains collected in the AM versus PM (n = 6 brains/point, male and female combined). G) Female 6E10 increase at 9 months compared to male 3xTg-AD (n = 6 brains/point, AM and PM combined). H) mOC78 merged AM, PM, male and female indicate 9, 12, and 16 and 20 months brains jump higher in than 2, 4, and 6-month-old 3xTg-AD brains and nTg steadily increases with age (n = 12 brains/point). I) mOC78 female brains harvested in the AM compared by age and genotype (n = 3 brains per point). J) mOC78 female brains harvested in the PM (n = 3 brain/point). K) Female mOC78 levels are higher than male levels (n = 3 brains/point).