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. Author manuscript; available in PMC: 2022 Dec 24.
Published in final edited form as: Compr Physiol. 2021 Sep 23;11(4):2371–2432. doi: 10.1002/cphy.c200028

Figure 1.

Figure 1

Global cerebral blood flow (CBF) is higher at 3 to 11 years of age than in adults. Arterial O2 content, CBF, cerebral O2 transport, cerebral metabolic rate of O2 (CMRO2), and O2 extraction fraction in first quantitative cerebral hemodynamic study in children with the nitrous oxide wash-in technique. Data from nine children were pooled from ages 3 to 11 years. Children at this age have higher CBF, O2 transport, and CMRO2, with comparable O2 extraction fraction as 12 adults undergoing the same technique. Source: Adapted, with permission, from Kennedy C and Sokoloff L, 1957 (221).