Table 3.
Comparison results of baseline data for different age groups in delta group.
| Variable | Age ≤18 years (n = 10) | Age 19–44 years (n = 40) | Age 45–64 years (n = 33) | Age ≥65 years (n = 13) | F/H/χ2 | P |
|---|---|---|---|---|---|---|
| Sex | 4.1568 | 0.2450 | ||||
| female | 3 (30.00) | 24 (60.00) | 17 (51.52) | 9 (69.23) | ||
| male | 7 (70.00) | 16 (40.00) | 16 (48.48) | 4 (30.77) | ||
| Classification | 0.0076∗ | |||||
| asymptomatic | 1 (10.00) | 0 (0.00) | 2 (6.06) | 1 (7.69) | ||
| mild | 7 (70.00) | 25 (62.50) | 14 (42.42) | 2 (15.38) | ||
| moderate | 2 (20.00) | 15 (37.50)e | 17 (51.52) | 9 (69.23) | ||
| severe | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (7.69) | ||
| Vaccination | <0.0001∗ | |||||
| No | 7 (70.00)abc | 1 (2.50) | 3 (9.09) | 0 (0.00) | ||
| Yes | 3 (30.00) | 39 (97.50) | 30 (90.91) | 13 (100.00) | ||
| Hematologic | ||||||
| WBC, ×109/L | 7.2022 ± 2.9467 | 6.0068 ± 1.413 | 6.2688 ± 2.2544 | 6.5308 ± 2.6983 | 0.88 | 0.4571 |
| PLT, ×109/L | 310.4444 ± 96.6309bc | 250.9 ± 73.0963 | 224.4848 ± 61.2317 | 192.6154 ± 55.078 | 5.97 | 0.0009∗ |
| NEUT, ×109/L | 3.94(2.02–4.39) | 3.615(2.75–4.46) | 3.36(2.56–4.37) | 3.9(2.36–5.21) | 0.0144 | 0.9995 |
| LYMPH, ×109/L | 2.3(2.18–2.65)bc | 1.6(1.22–2.065) | 1.58(1.27–2.08) | 1.62(1–1.74) | 11.8874 | 0.0078∗ |
| MONO, ×109/L | 0.7078 ± 0.1975 | 0.5823 ± 0.1726 | 0.6403 ± 0.2539 | 0.6377 ± 0.242 | 1.03 | 0.3841 |
| Coagulation function | ||||||
| PT, s | 12.4444 ± 1.4689 | 12.0375 ± 1.0392 | 11.5939 ± 0.9401 | 11.7077 ± 0.697 | 2.25 | 0.0875 |
| FIB, g/L | 2.7378 ± 0.7957 | 3.0403 ± 0.6101 | 3.143 ± 1.0312 | 2.9962 ± 0.7096 | 0.61 | 0.6110 |
| APTT, s | 32.6(28.5–35) | 28.65(26.4–31.4) | 28.1(25.4–29.5) | 28.9(28–30.5) | 7.4570 | 0.0587 |
| TT, s | 15.2222 ± 1.8586 | 13.75 ± 1.3582 | 14.5394 ± 1.8985 | 14.1769 ± 2.1222 | 2.40 | 0.0731 |
| Liver and renal function | ||||||
| ALT, U/L | 17.25(9.3–85.3) | 18.75(11.5–34.35) | 23(17.9–30.7) | 21(17.7–25.6) | 1.8720 | 0.5994 |
| AST, U/L | 24.9(17–64.65) | 16.2(13.85–21.05) | 18.9(16.1–26.5) | 22.9(17.8–25.9) | 9.8124 | 0.0202∗ |
| AST/ALT | 1.475 ± 0.7998 | 0.9685 ± 0.3887 | 0.9485 ± 0.297 | 1.0962 ± 0.2495 | 5.7103 | 0.1266 |
| TBIL, umol/L | 5.25(4.55–9.25) | 9.35(6.85–12.55) | 10.3(7.6–13.4) | 8.1(6–10.7) | 6.7904 | 0.0789 |
| LDH, U/L | 167(133.5–212.5) | 131.5(114–144.5)e | 152(127–172) | 169(151–191) | 19.0113 | 0.0003∗ |
| BUN, mmol/L | 3.95(3.47–5.375) | 3.88(3.415–4.52) | 4.34(3.71–5.27) | 4.48(4.03–5.56) | 5.5250 | 0.1372 |
| Cr, umol/L | 47.5(41–53.55)ab | 63.55(58–81.65) | 71.8(58.1–78.5) | 64.4(53.4–76.8) | 11.9213 | 0.0077∗ |
| BUN/Cr | 0.08(0.07–0.12)a | 0.05(0.04–0.07)e | 0.07(0.05–0.07) | 0.07(0.06–0.08) | 17.4821 | 0.0006∗ |
| UA, umol/L | 347.6875 ± 85.7932 | 330.835 ± 89.9001 | 334.8091 ± 99.0559 | 274.1385 ± 66.9378 | 1.72 | 0.1676 |
| Virus shedding time, day | 10.4 ± 3.5024 | 11.8 ± 4.7566 | 13.1212 ± 4.9671 | 15.2308 ± 4.0446 | 2.68 | 0.0515 |
| Hospitalisation time, day | 13.6 ± 3.2042 | 14.975 ± 3.9645 | 16.3333 ± 4.4418 | 17.6923 ± 3.521 | 2.68 | 0.0514 |
| ORFlabCT | 21.7713 ± 4.8978 | 21.8006 ± 5.4918 | 20.8736 ± 5.407 | 20.2515 ± 6.5323 | 0.31 | 0.8176 |
| NCT | 19.6038 ± 6.1546 | 19.1443 ± 6.1276 | 18.5566 ± 5.7653 | 17.2415 ± 5.9964 | 0.39 | 0.7622 |
| IgG, AU/ml | 0.09(0.03–7.13) | 6.79(2.105–24.22)d | 1.48(0.22–4.88) | 2.76(0.72–30.13) | 11.9656 | 0.0075∗ |
| IgM, AU/ml | 0.04(0.04–0.06) | 0.13(0.045–0.445)d | 0.04(0.03–0.12) | 0.05(0.04–0.31) | 8.7886 | 0.0322∗ |
| NLR | 1.8241(0.8783–2.125) | 1.9958(1.5773–3.1924) | 1.9234(1.4891–3.4932) | 2.5843(1.5029–3.9) | 3.9451 | 0.2675 |
| CRP, mg/L | 1.5(0.499–2.36) | 2.275(0.499–7.93) | 2.56(0.5–7.41) | 6.93(2.44–9.07) | 5.1480 | 0.1613 |
| D-D, ug/mL | 0.42(0.39–0.47) | 0.48(0.43–0.535) | 0.5(0.45–0.58) | 0.56(0.5–0.64) | 8.7015 | 0.0335∗ |
| CK, U/L | 55.17(45.455–82.145) | 60.295(45.075–99.63)d | 89.92(69.84–161.53) | 81.76(57.15–119.38) | 8.9571 | 0.0299∗ |
| Cytokines | ||||||
| IL-2, pg/ml | 1.24(0.99–1.81) | 0.95(0.675–1.875) | 1.08(0.61–1.83) | 0.55(0.4–1.05) | 4.5442 | 0.2084 |
| IL-4, pg/ml | 2.17(1.92–2.67) | 1.97(1.505–2.4) | 1.76(1.29–2.38) | 1.72(1.59–2.63) | 2.1922 | 0.5335 |
| IL-6, pg/ml | 3.38(1.12–4.97) | 2.06(0.9–4.32) | 2.755(1.54–7.905) | 4.5(2.8–7.95) | 4.8745 | 0.1812 |
| IL-10, pg/ml | 4.13(3.02–4.75) | 3.99(3.02–5.26) | 4.58(2.79–6.6) | 4.92(3.45–8.31) | 2.1408 | 0.5437 |
| TNF-α, pg/ml | 4.42(3.5–4.62) | 3.165(2.405–3.785) | 2.71(2.15–3.71) | 2.49(2.21–2.98) | 6.9989 | 0.0719 |
| IFN-γ, pg/ml | 1.23(1.12–1.29) | 1.09(0.84–1.725) | 1.26(1.07–1.5) | 1.6(1.11–1.64) | 5.4030 | 0.1446 |
| Lymphocytes | ||||||
| Lymph, Cell/ul | 2329.4444 ± 594.7926abc | 1507.575 ± 522.4229 | 1513.697 ± 620.797 | 1334.25 ± 765.9797 | 5.69 | 0.0013∗ |
| T lymph, Cell/ul | 1688.7778 ± 438.3742abc | 1089.525 ± 417.9818 | 1050.0606 ± 468.1702 | 802.9167 ± 341.3584 | 7.69 | 0.0001∗ |
| T4 lymph, Cell/ul | 777(655–847)c | 615(437–762) | 625(416–766) | 457(236.5–627) | 8.9977 | 0.0293∗ |
| T8 lymph, Cell/ul | 603(529–735)abc | 402(307.5–550) | 337(262–487) | 317.5(208.5–349.5) | 17.2227 | 0.0006∗ |
| B lymph, Cell/ul | 346(321–501)abc | 207.5(133–267) | 159(99–256) | 137.5(53–216) | 16.3686 | 0.0010∗ |
| NK lymph, Cell/ul | 204(170–259) | 182(115.5–264) | 254(148–345) | 262.5(156.5–486.5) | 3.7573 | 0.2889 |
| DPT, Cell/ul | 22(17–25) | 15.5(10.5–26) | 19(15–40) | 14(9.5–20.5) | 6.6659 | 0.0833 |
Note: “a” indicates that the difference between the two groups of age≤18years and age 19–44 years are statistically significant; “b” indicates that the difference between the two groups of age≤18 years and age 45–64 years are statistically significant; “c” indicates that the difference between the two groups is age≤18 years and age ≥65 years old is statistically significant; “d” means the difference between the age 19–44 years old and age 45–64 years old groups is statistically significant; "e” means the age 19–44 years old and age ≥65 years old groups are between the two groups The difference is statistically significant; “f” indicates that the difference between the age 45–64 years and age ≥65 years old groups is statistically significant. “∗” indicates that the difference in the four groups are statistically significant.